Breast Cancer Research Studies
TRIPLE NEGATIVE
BR003: A Randomized Phase III Trial of Adjuvant Therapy
Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with
or without Carboplatin for Node-Positive or High-Risk Node-Negative
Triple-Negative Invasive Breast Cancer.
WO39391: A Phase III, Randomized, Open-Label Study Comparing Atezolizumab (Anti-PD-L1 Antibody) in
Combination with Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus
Chemotherapy Alone in Patients with Operable Triple-Negative Breast Cancer
NODE+ / HIGH RISK NODE - / HER2-
A011502: A Randomized Phase III Double-Blinded
Placebo-Controlled Trial of Aspirin as Adjuvant Therapy for Node-Positive HER2
Negative Breast Cancer: The ABC Trial.
INFLAMMATORY
S1706: A Phase II Randomized Trial of Olaparib (NSC-747856) Administered
Concurrently with Radiotherapy versus Radiotherapy alone for Inflammatory
Breast Cancer
DCIS
AFT-25: Comparison of Operative to Monitoring and
Endocrine Therapy (COMET) Trial for Low Risk DCIS: A Phase III Prospective
Randomized Trial
METASTATIC
A171601:
A Phase II Trial Assessing the tolerability of Palbociclib in Combination
with Letrozole or Fulvestrant in Patients aged 70 and older with Estrogen Receptor
Positive, HER-2 Negative Metastatic Breast Cancer
BR004: A Randomized, Double-Blind, Phase III Trial of
Paclitaxel/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line
HER2-Positive Metastatic Breast Cancer
POST NEOADJUVANT
A011202: A Randomized Phase III Trial Comparing Axillary
Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (CT1-3N1)
who have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy.
B-51: A Randomized Phase III Clinical Trial Evaluating
Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional
Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant
Chemotherapy who Convert to Pathologically Negative Axillary Nodes After
Neoadjuvant Chemotherapy.
EA1131: A Randomized Phase III Post-Operative Trial of
Platinum-Based Chemotherapy Vs. Capecitabine in Patients with Residual
Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy.
S1418: A Randomized Phase III Trial to Evaluate the
Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple
Receptor-Negative Breast Cancer with ≥ 1cm Residual Invasive Cancer or Positive
Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy.
CANCER CONTROL
A011404: Randomized Phase III Trial Evaluating the Role
of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early
Breast Cancer
A221505: Phase III Randomized Trial of Hypofractionated Post Mastectomy
Radiation with Breast Reconstruction
CC004: Phase II Double Blind Dose-Finding Trial of
Bupropion Versus Placebo for Sexual Desire in Women with Breast or Gynecologic
Cancer
WF-97116: A Phase 3 Placebo-Controlled Clinical Trial of
Donepezil in Chemotherapy Exposed Breast Cancer Survivors with Cognitive Impairment
CANCER CARE DELIVERY RESEARCH
S1415CD: "TrACER": Trial Assessing CSF
prescribing Effectiveness and Risk